They proposed the synthesis of potent IP3 5-phosphatase inhibitors, l-chiro-inositol 1,4,6-trisphosphate, along with the corresponding trisphosphorothioate and evaluated their potencies [49].
Although liposomes have proven useful for the delivery of drugs and gene therapy vectors, their potencies are often compromised by poor unloading following uptake into their target cells.
The relationship between their structures and their potencies, demonstrated in the current study, will be useful for the design of optimal agents.
In functional assays Cl-IB-MECA and IB-MECA were able to inhibit cyclic AMP accumulation and their potencies were statistically increased after exposure to PEMFs.
Derivatives 21 and 22 proved to be the most active within the series and their potencies against AChE were in the same order of magnitude of the reference compounds.
Of the four antiepileptic drugs tested in this model, only phenytoin proved ineffective, while valproate, gabapentin and carbamazepine varied in their potencies, with only the latter drug proving to be completely efficacious.
