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In addition to their lowering effects on cholesterol levels, a number of other clinical benefits of statins have been recognized [5].
Statins, selective inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, are first-line drugs in the treatment of hypercholesterolemia due to their lowering effect on LDL-cholesterol [ 21].
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Much of their success can be found in their lower body and legs.
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