Sentence examples for their long circulation from inspiring English sources
However, their long circulation time in blood makes them unsuitable as imaging probes.
82 Carbon nanotubes (CNTs) have attracted much attention in drug delivery research due to their long circulation time and the efficient methodologies for chemical modification.
Due to their size and long circulation time, typical nanotherapeutics predominately base their targeting mechanism on exploiting the enhanced permeation and retention (EPR) effect that typically characterizes the tumor-associated vasculature.
This is partly due to their long blood circulation time and plasma stability.
The incorporation of hydrophilic polyethylene glycol on the surface of liposomes further improves their properties of low opsonization and long circulation time [43].
Most historic (1978 2008) PEDV strains from Europe and Asia contain these INDELs/SNPs in their S protein, suggesting that these changes could contribute to their long-time circulation (endemic) in swine populations, potentially causing only mild disease.
By contrast, when P2VP blocks and the targeting unit were buried by the PEO shell at physiological pH, micelle stealth properties were improved, allowing their future systemic injection with an expected long circulation in blood.
The UK government body, the Medicines and Healthcare Products Regulatory Agency MHRAand and the US Food and Drug Administration FDAareare now reviewing all forms of graphene and functionalized graphene oxide (GO) due to their poor solubility, high agglomeration, long-term retention, and relatively long circulation time in the blood (Begum et al. 2011).
The long circulation time of intact antibodies is beneficial for their therapeutic outcome.
In nanomedicine, particular care has to be taken with the particles' surfaces to avoid innate immune system recognition and to secure sufficiently long circulation half-lives for the agents to reach their targets [41].
However, the long circulation times of most nanoparticle-based imaging agents and their tendency to be taken up by macrophages can be a disadvantage for some clinical applications.
