Sentence examples for their integration site from inspiring English sources

Among other factors, the transcriptional activity of recombinant genes strongly depends on their integration site within the genome.

Around 30 such groups have been described based on a phylogenetic analysis of pol sequences; they vary in copy number from one to a few thousand 10, specific proviruses showing unique flanking sequences depending on their integration site.

This phage resembles φ11/φETA and φMu50β carried by the MRSA isolate Mu50, although their integration sites differ (Figure 2).

It is not clear whether separate DNA fragments for Cre transgene and 120-kb-BAC used during the pronucleus injection may increase the chance in disrupting unknown gene(s) or sequences at their integration sites, independent of the NMDA receptor function.

However, there is an unmet need for a simplified tool for biologists with no previous experience or knowledge of informatics to analyse the data generated by whole-exome, transcriptome or genome sequencing using NGS technology to detect the presence of HPV sequences along with their integration sites.

We noted that reactivation in response to knockdown of Atf7ip and DNA methylation inhibition occurred in approximately 12% of GFP-reporter MEFs and in only approximately 2% of H2B-citrine Xi-reporter MEFs based on flow cytometry measurements, which is potentially due to different levels of DNA methylation, other chromatin marks, and/or their integration sites.

Analyzing stochastic expression of a stably integrated fluorescent reporter in six isogenic cell populations, differing only in their reporter integration site, this study provides new evidence suggesting that the local chromatin environment (reporter insertion site) influences stochastic gene expression.

The primers contain a sequence complementary to the loxP sites on pUG6/pUG66 at their 3′ end and a sequence complementary to the flanking regions of the genomic integration site at their 5′ end.

Recent reports [28], [29] further characterized patients in whom insertional mutagenesis was observed: their analysis of integration sites and chromosomal rearrangements support the multi-hit leukemogenesis theory.

These vectors differ in their efficiency of gene insertion, genetic cargo capacity, integration site preferences, and effects on chromosomal stability.

Their study suggested that HIV-1 integrase has the potential to select the integration site.