Exact(36)
The assembled mPing sequences were classified into subtypes based on their breakpoints and point mutations compared with the four canonical mPing subtypes.
The exceptions were two t(8 21) complex translocations resulting in detectable quantitative CNA at their breakpoints.
In three out of the 20 deletions there are small insertions at their breakpoints, and no extensive homology, therefore we suggest these have been mediated by NHEJ.
A major drawback of the classical deficiencies is the imprecise mapping of their breakpoints, which is often based on complementation data with alleles of only a few genes.
Twenty-eight duplicons have been described within the Mamu-A region (alpha block) and HERV16 sequences appear to map directly to their breakpoints [14].
This enrichment of microhomology was also found when the analysis was repeated using only deletions with Alus at their breakpoints, as well as using only deletions with no Alus at their breakpoints, indicating that microhomology is not specifically associated with the Alu elements.
Similar(24)
By design, WES did not detect genome rearrangements in introns, translocations and their breakpoint, and repeat expansion disorders.
Barrier islands are formed in those areas where the coastal slope is flatter than the equilibrium slope required by the long constructive swells i.e., the waves that build up the foreshore in front of their breakpoint.
Their breakpoint was chosen at 4 y which is exactly in the middle of the age interval 2 6 y.
Although no brain sequences were available for the lymphoma patients AM and IV, their breakpoint results looked somewhat similar to the dementia patients.
In both groups of AML, 25 cytogenetically balanced translocations (table 1, 2 tables 4 and 5) did not show any cryptic rearrangement (gain or loss) at their breakpoint locations.
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