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Clusters differed by their AG percentages (P<0.001; Figure S3) and their aberration patterns.
We investigated the properties of affected introns and their aberration from constitutively spliced ones.
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They then accept, in some measure, that its errors are their errors, its aberrations their aberrations, and that any revolt will be against them.
Conventional fisheye lenses can map flat image onto wide field of view, but suppressing field curvature and their aberrations needs multi-layer components, and thus imposes harsh design tradeoffs.
"Are their aberrations?
Their aberrations and deranged cross-talks lead to pathological conditions [ 1].
This assumption is also consistent with the possibility that subclones' viability may be hindered by the lethal synergy of some of their aberrations.
We next examined the key players or mechanisms that increased the ubiquitination and degradation of Mcl-1 and Bcl-2 in mammary epithelial cells as well as their aberrations in breast cancer cells.
While the key components of the RB pathway qualify as proto-oncogenes or tumour suppressors, and their aberrations may provide direct proliferative advantage to cancer cells, defects in the so-called checkpoint mechanisms that monitor and help ensure the error-free execution of the cell-cycle transitions act more indirectly, yet affect both tumour progression and response to anti-cancer therapy.
Using pathway data from five databases (1994 pathways) and expression data from eight cancers (2210 samples), we first infer the aberrant pathways in individual tumours, thus defining their pathway aberration profiles.
Since MMO displayed no significant copy number variation compared to the parental cell lines, we further wanted to determine whether different cell subpopulations of SUM159 exhibit distinct differences in their genomic aberration profiles.
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CEO of Professional Science Editing for Scientists @ prosciediting.com