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But semantically that is the wrong alignment.
These degradations can take the form of strange objects that appear in the images, or they may also be due to the wrong alignment of the sheets in the image.
These results show that it is essential to utilize alignment mapping quality to reduce the FPR caused by the wrong alignment of short NGS sequences with low to medium sequencing depth.
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Among these, the second step is the most critical because a wrong alignment between the target and templates will systematically lead to misfolded models [7].
However, as BWA-SW deploys heuristic rules, the chance of producing a wrong alignment is also related to the heuristics.
Flow cell tilt is measured automatically with current software versions; if a too high value is determined, a wrong alignment of the flow cell in the instrument is a likely source.
This is especially important when developing new GIA models, since neglecting this problem can easily lead to wrong alignment of the ice and sea-level histories, particularly close to the deglaciation areas, like Antarctica.
As shown in Figure 10A and B, our method aligns the local structure well, whereas HHalign seemingly produces a totally wrong alignment.
Today we know that many factors seem to play a causal role in OA, including hereditary predisposition, wrong alignment of limbs, mechanical overloading, chronic inflammation, stress, obesity, ageing, and hormones [ 4, 5].
The alignment error rate, which is the fraction of wrong alignments out of confident mappings in simulation (see also Section 3.2), only increases from 0.08%to0.11%1%.
In other situations, the numerical scores of biologically correct alignments turned out to be below the scores of biololgically wrong alignments returned by the non-anchored version of our program.
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