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Globally, 58.4% of the wounds achieved closure.
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Open image in new window Fig. 5 Showing corrugated drains Open image in new window Fig. 6 Showing loop suture technique Open image in new window Fig. 7 Showing complete approximation of the wound achieved with loop suture technique.
On NPWT removal, a split-thickness skin graft was applied on the wound, achieving complete and uneventful healing.
Most wounds achieved apposition of >50 % with 18.6 % wounds closed by sutures and 18.5 % wounds closed by LBSS resulting in 100%% apposition which was not statistically significant (p = 0.906).
All 14 patients (100%) with nonischemic wounds and 55 of 75 patients (73.3%) with ischemic wounds achieved primary healing (P = 0.06).
In our case series we employed the sural fasciomusculocutaneous flap on large wounds, achieving full reconstruction of soft tissues and successful coverage of internal hardware in three cases.
Vascularization of wound, achieved both by angiogenesis (formation of blood vessels from preexisting ones) and vasculogenesis (formation of blood vessels from endothelial progenitor cells), is necessary for quick and effective tissue repair.
Histological examinations reveal that, more than 50% of re-epithelialization and regeneration of the wound are achieved by dressing it with the chitosan/γ-PGA PECs.
Any further wound dressing will follow the allocated treatment until definitive closure/cover of the wound is achieved.
The wound was achieved by scratching across the center of each well with a 200 μl pipette tip followed by a PBS wash to remove debris.
After hemostasis was achieved, the wounds were closed.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com