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The phrase "the worst affected" is correct and usable in written English.
This phrase is used to refer to people or places that have been more adversely impacted by an issue or event than others. For example, "The small towns were the worst affected by the flooding, as they lacked the resources to rebuild."
Exact(58)
Syria's children are the worst affected.
Banks are the worst affected.
He has announced he will visit the worst affected areas.
Thousands of paramilitary forces moved into the worst affected districts.
The capital is among the worst affected cities.
For the worst affected, this could exceed £10,000.
The worst affected areas are in the reef's north.
Shanghai is often cited as the worst affected city.
After Cologne, Hamburg appears to have been the worst affected.
Similar(2)
The worst-affected countries are Liberia, Sierra Leone and Guinea.
This means effort can be focused on the worst-affected places within a country, not just on the worst-affected countries.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com