The widespread functions of ZEB proteins in human malignancies indicate their significance.
The widespread functions of Cdk5 in nervous system development have confounded efforts to understand the role of mammalian Cdk5 in neurodegeneration in vivo.
The widespread functions regulated by Hsf1 explain its binding to a large number of promoters (about 3%% of the genes in the yeast genome).
In the absence of high quality evidence of improved patient important outcomes such as decreased time to weight bearing and earlier return to function, the widespread use of bone stimulators represents an uncertain investment of limited healthcare resources.
Here we show that dysbindin-dependent regulation of surface receptor expression is not restricted to neurons or to the D2 receptor, and identify an apparently widespread function of dysbindin in regulating GPCRs by promoting their sorting to lysosomes after endocytosis.
These results identify a distinct, and potentially widespread function of dysbindin in promoting the sorting of specific GPCRs to lysosomes after endocytosis.
However, the expression patterns of SlGRAS24 and SlGRAS40 in tomato are largely different, which suggests that the complicated and widespread functions of the miR171-GRASs regulatory networks in tomato.
However due to widespread function and highly pleotropic nature, Notch inhibition raises the possibility of unanticipated adverse effects in host tissues including gastrointestinal toxicity after GSI treatment or formation of vascular tumors after DLL4 ligand blockade [ 4, 5].
