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The strong and moderate (score 3 and 2, respectively) hormone receptor expression occurred mostly in sarcomas of uterus, pelvis and breast, while the weak (score 1) expression of both ER and PGR was surprisingly evenly distributed among location, gender and age.
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Secondly, the weak scores of private pre-registered students might not be surprising.
For the clustering, strong interactions were given a weight of 3 while the weakest interactions were given a weight of 1, such that the weak scores were closest to non-interactions, shown in black, and the strongest would be the brightest yellow.
The clustering algorithm required the weight of the scores to be reversed: we defined 3 as the strongest score and 1 as the weakest score so that weak scores were closest to non-interactions.
The weaker score obtained with ompA was due to an insertion of 12 nt versus the environmental strain, nucleotides not present in the other isolates from human origin.
While the characteristics that have the weakest scores were need of autonomy and risk-taking propensity.
At the other end of the spectrum, telecommunications, energy and diversified financial companies earned the weakest scores.
However, additional statistical power is gained in the Uncertainty and Specificity statistics with increasing number of downstream gene expressions in a HYP, such that the weaker scores of larger HYPs can be just as significant and meaningful as higher scores from smaller HYPs.
The expression of VEGF-C in tumour cell was classified based on the staining intensity as follows: score 0 if no staining was detected; score 1 if the staining intensity was weak; score 2 if the intensity was moderate; score 3 if the intensity was high; VEGF-C status in tumour cells was finally classified as low expression (score 0 or 1) or high expression (score 2 or 3).
Expression of pHER1 was evaluated in 264 cases and 18% had a detectable membrane staining, of which the majority were weak (score 1) and a few showed moderate intensity (score 2).
In all 14 cases of IHC discordance one pathologist assessed the tumor as having no PTEN staining (score 0) with the other pathologist recording weak (score 1) staining.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com