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Typically, variants of a particular locus are provided as different target sequences, and the presence of the variant in the data set being interrogated is revealed by a successful assembly outcome.
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Third, we found that although coverage of common variation in the exon pilot dataset by the variants in the low coverage pilot data is very high, its coverage of low frequency variants by the variants in the low coverage pilot dataset was very poor.
However, there was no evidence for this abnormality related to the variants in the TCF7L2 gene during the hyperglycaemic clamp (data not shown).
Traditionally, the first few PCs are used in data analysis, since they retain most of the variants among the data features (in the original data set), and eliminate (by the projection) those features that are highly correlated among themselves; whereas the last few PCs are often assumed to retain only the residual noise in the data [23, 57].
Additionally, we assessed the frequency of the variant in whole-exome sequencing data from 489 white healthy controls of UK and US origin and in European cases listed in publicly available data sets of genetic variation (1000 Genomes, Exome Variant Server and Exome Aggregation Consortium).
One major concern was the likely under-representation of low fit variants in the data set that could have led to false conclusions towards epistasis [29].
The time of training a new model looks linear for the number of variants in the data set.
This may be an over estimation of error probability for some buckets when the mismatches resulted from real variants in the data are included.
This is caused by a large excess of rare variants in the data set of the 67 segregating sites, 51 are singletons.
The imperfection of a phylogeny is defined as the difference between the number of point mutations found in the tree and the number of variant sites in the data set.
The frequency of this variant in the read data was 27% (Table 3).
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