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In the proposed approach, the frequency response function is mapped onto a probability distribution function where the mean value of the probability distribution function becomes the resonance frequency and the variance corresponds to its bandwidth.
These distributions are taken to be normal distributions that have the scaled predicted protein level as their mean and the variance is estimated from observed protein levels (i.e. the variance corresponds to the standard deviations shown in Fig. 2 c).
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The main source of variability in the data (principal component 1 and 2; > 71% of the variance) corresponded to time-related expression changes that reflect chronological vascular development11.
The last two with a lesser eigenvalue (1.28 and 1.08% of the variance) corresponded to items 1 to 7, yielding two small factors of the original somatisation scale.
Alter et al. were able to adjust for non-biological variation by inferring that the combinations of genes and arrays that contributed the most to the variance correspond to non-biological artifacts.
The variances correspond to (18).
The first direction of variance corresponds to the degree of wear of the tooth, and hence appears as a signal superimposed to the intrinsic variance by contingent factors during the late life of the animals.
In most of the cases, the first axis (representing from 40to55%5% of the total variance) corresponded, as expected, to the difference between both parental strains with the F1 and F2 hybrids in between.
The remaining 10% of unexplained variance corresponds mostly to experimental error, thus leaving little room for genetically induced variability that cannot be traced to envirome data.
The residual between-study variance remained stable, the best fit (smallest residual between-study variance) corresponds to an odds ratio of 1.75.
The tradeoff between flexibility and smoothness is controlled by the variance parameter τ j 2. A large variance corresponds with a rough estimated function, and vice versa.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com