The difficulty mainly comes from the variability and sparsity of human image data, which impairs traditional metric learning models based on point-wise dissimilarity.
The automatic segmentation of the brain with normal perfusion avoids the potential user variability and difficulty caused by manual selection of normal brain parenchyma.
Animal models may overcome many of the limitations of the application of genomic technology to humans, including the need for repeated encoscopy, the large genetic and phenotypic variability, and the difficulty of studying the initial stages of the disease.
The variability in presentation of ATBAD and subtlety of symptoms in some cases add to the complexity and difficulty of defining complicated versus uncomplicated dissections.
The 10 tropes attributed to Aenesidemus showed the difficulties encountered by attempts to ascertain the truth or reliability of judgments based on sense information, owing to the variability and differences of human and animal perceptions.
However, the use of human bone tissue is associated with practical issues such as availability of tissue, donor-related variability and difficulty in maintaining the functionality and viability of the implant (Holzapfel et al., 2013; Hutmacher et al., 2009).
Among the limitations are the small sample size and the possible interobserver and intraoberserver variability due to multiple study members and difficulty of standardising the index test.
The ability to measure changes in host mRNA levels during infection is greatly limited by the intrinsic variability of the tissue and the difficulty of accurately reproducing infection across multiple replicates.
In light of variability in the data and the difficulty of interpreting general outcomes from the available studies, there is a tendency toward standardizing the definition of bleeding.
However, all this flexibility comes with a catch: as the combinatorial complexity of optional design features and deployment variability increases, the difficulty of assessing system qualities such as scalability and quality of service increases too.
