When a new mathematical conjecture is proven, there may be initial debate as to the validity of the proof but upon community validation, the debate ends.
In order to be sure of the validity of the results, experimental validation is necessary.
This study has two objectives: (1) to examine the inter- and intrarater reliability of the PPS by clinicians, (2) to examine the validity of the PPS by content validation, questioning clinicians on its purpose and usefulness.
Furthermore, main study results will be used to evaluate the validity of the model(s) with internal validation techniques (bootstrapping) and cross validation between the three settings whereby each setting acts as a test-population for model(s) developed in the other settings [ 81].
A numerical validation demonstrates the validity of the method by adequately predicting the displacement distribution of a mechanically loaded lattice structure, but an experimental validation raises issues related to the manufacturing limitations of small struts.
Independent validation shows the validity of the results from this meta analysis and confirms SERPINA1 as a potent mRNA marker for PTC in a total (meta analysis plus validation) of 181 samples.
Further studies are needed to confirm the validity of the results in a larger validation population.
Regarding Cyclin D1 evaluation, we are confident in the validity of the due to the extensive validation of the IHC methodologies in the literature [ 20, 28, 32, 33].
Despite such robust findings regarding the validity of the hierarchical model, cross-cultural validation and feasibility of the model have not been actively examined.
To determine the validity of the two Peak Day algorithms (validation sub-study) compared to urine hormone monitoring, we calculated percent agreement for EDO based on expert review of the "last fertile sign" and "best quality" Peak Day algorithms, and the CBFM for the same day, and within ≤1, ≤2, and ≤3 days.
