A health research system is defined as the people, institutions, networks and activities whose primary purpose is to generate, communicate and promote the utilization of scientifically validated knowledge that can be used to enhance, restore and/or maintain the health status of populations [ 23].
Consequently, after more than 40 years intensive molecular genetics research in this bacterium, including the recent high throughput studies [ 43, 44, 57, 58], our experimentally validated knowledge of the transcriptome and gene regulatory systems in E. coli K12 is the most complete currently available for any organism [ 46, 51].
Given the common agreement to treat CIN III lesions by surgical removal of transformed tissue, validated knowledge about the natural history of these lesions is surprisingly limited.
This however creates a severe challenge: how to ensure that robust, reliable, validated knowledge about the future is made available to less resource-rich organizations.
Biofilter utilizes biologically validated knowledge of the relationships between sets of genes to build pairwise SNP-SNP models from functionally linked gene-gene pairs.
The quality of a candidate model organism is then determined by the degree to which the identified subsystems match genetic pathways from validated knowledge.
Validated knowledge starting on the level of individual plants and plant populations was used.
At the end, this paper contributes to: (1) a validated knowledge transfer analysis framework supporting DM resilience endeavors; (2) demonstrate the DSR methodology as a frame for IS research.
The fact files were applied to build a comprehensive, validated knowledge base for primary immunodeficiencies (PIDs) called ImmunoDeficiency Resource (IDR) [ 23, 24].
Finally, the developed approach must be coherent and continuously updatable, supporting the unified framework required to ensure that we acquire sufficient, rigorously validated knowledge formulation of a robust reliable ITS and RA as quickly as possible.
