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Major physiological functions that are controlled by DtxR in response to the iron level include the expression of the diphtheria toxin [ 12], the synthesis and export of siderophores [ 14], the siderophore-dependent uptake of iron [ 16], and the synthesis of specific systems for the utilization of iron from heme, hemin and hemoglobin [ 17, 18].
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Further analysis of the C. variabile DSM 44702 genome sequence revealed the presence of 29 genes with predicted functions in the utilization of iron-siderophores, named either siu (siderophore-iron utilization protein) or sii (siderophore-iron interacting protein).
It has long been known that inflammation can mimic some aspects of iron deficiency by impairing the utilization of existing iron stores for red cell production and inducing an iron-sequestration syndrome and low serum iron.
Pathogenic bacteria have evolved various iron acquisition mechanisms for the utilization of extracellular iron sources, with siderophore secretion and uptake being one of the most effective systems.
Taken together, these results suggest that colonization of distinct anatomic sites involves the utilization of different iron sources.
In light of this the utilization of dietary iron supplementation to resolve anemia associated with chronic schistosomiasis may result in more severe long term disease outcomes.
The corresponding hemin binding protein HtaA is probably associated with the cell envelope and involved in the utilization of heme iron [ 33].
The role inflammation impairing the utilization of existing iron stores has been explained previously; recent articles focus on critically ill patients and the attempts to introduce Ret He in the transfusion area improving the management of anemic patients in critical conditions [ 56, 57].
This review mainly focuses on, (i) the structure and function of the ferritins in vertebrates, plants, and bacteria, (ii) ferritin function in iron deposition and release, (iii) the utilization of ferritin in iron supplementation and the challenge of ferritin as an iron supplement, and (iv) the application of ferritin in the encapsulation of bioactive compounds.
These novel abilities are consistent with Bordetella studies showing that FbpABp is required by these respiratory pathogens for the utilization of both inorganic iron and siderophore-bound iron.
Copper is involved in the formation of red blood cells, the absorption and utilization of iron, the metabolism of cholesterol and glucose, release of life sustaining proteins and enzymes.
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