Sentence examples for the upfront use from inspiring English sources
In Her2-positive advanced breast cancer, the upfront use of trastuzumab is well established.
In addition, trials examining newer agents in the castration-naïve setting are now beginning to emerge, potentially supporting the upfront use of agents such as docetaxel.
In particular, clinical trials have shown that NSCLC patients whose tumors harbor sensitizing EGFR mutations significantly benefit from the upfront use of an EGFR TKI, rather than conventional chemotherapy.
Both combined and sequential single agents are acceptable options; however, if not contraindicated by the conditions of the patient and if feasible with an acceptable toxicity profile, there is no reason to delay the upfront use of active agents.
Based on these encouraging data, the upfront use of bortezomib in combination with conventional chemotherapy has been tested in younger patients before HSCT and in elderly patients who are not HSCT candidates.
Expectedly, the upfront use of combined bortezomib and chemotherapy has resulted in a CR rate of about 20 30% in elderly patients [ 9] and a more encouraging CR rate of about 50% in younger patients when followed by auto-HSCT [ 10, 11].
Also, Time Warner Cable works on a calendar year, Ms. Gillman says, rather than the fall-to-spring season that the upfronts use.
While addressing one aspect of the sequencing debate, such upfront use clearly then raises a whole raft of new questions about management on development of CRPC.
The press and Wall Street tend to focus on the upfront and use it as a barometer for the health of television media, but it's a faulty barometer.
It is also important to remember that upfront use of an aromatase inhibitor probably precludes the use of other aromatase inhibitors after 5 years of therapy, an approach that demonstrated significant benefit in the MA-17 trial.
Moreover, upfront use of bortezomib in combination with chemotherapy has resulted in a CR rate about of 20% (17 43%) even in the absence of auto-HSCT [ 5, 6].
