Apart from measuring differential expression across genetic types, we studied differential co-expression with regulatory factors, thus improving the understanding of the gene expression data and increasing the biological knowledge generated from the experiment.
These findings of different frequencies of mutation types in PHP1a/ PPHP and POH may contribute to the understanding of the variable expression of these disorders; however, it should be noted that several mutations are shared by both POH and PPHP patients and the mechanisms that determine the altered phenotypic expression of these mutations remain to be elucidated.
The examination of PTSD terminology defined two completely different tasks: the understanding of the meaning of the expressions used by the patient; and the search for terms that translate such expressions into medical language.
To facilitate the understanding of the association between gene expression and DNA methylation at the individual gene level, we used four thresholds (two for gene expression and two for methylation) to categorize each gene into nine categories.
The understanding of the time course of expression of cerebrospinal fluid (CSF) biomarker levels following severe TBI is an important step toward using these biomarkers to measure injury severity and/or early response to therapeutic interventions.
Here, we review several model systems that have been developed to advance the understanding of the role of SNCA expression levels in the etiology of synucleinopathies.
This study identified genes implicated in behavioural differences related to social dominance, which contributes to the understanding of the relationship between gene expression and behavioural plasticity in the context of competitive interactions between native and invasive species.
The understanding of the mechanisms regulating their expression will provide a potent tool for immuno-therapies and will complete our growing knowledge on T cell activation and contraction in health and disease.
Among the most notable posttranscriptional events studied are the widespread usage of alternative splicing, the pleiotropic regulatory roles of miRNAs, and breakthroughs in the understanding of the control of gene expression by noncoding RNA transcripts.
These strategies are designed to provide heterozygote identification, prenatal diagnosis and gestational management, the development of rational therapies, and the understanding of the molecular basis of disease expression.
