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This has the clear advantage that it provides a transparent link between parameter values and experimental data in comparison to alternative methods such as simplex optimisation [ 12], simulated annealing [ 13] and Levenberg-Marquart optimisation [ 14], which only provide parameter value estimates without increasing the understanding of the underpinning model mechanisms.
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The realization of 'intelligent and resource aware' distributed enterprises requires substantial development of the underpinning modelling, information management and knowledge representation technologies.
Successful extrapolation from rats to humans has been made for thiopental but the underpinning modelling was based on extensive prior knowledge of tissue kinetics [ 11].
The lack of an underpinning model also enables great flexibility, as the interactions between genes are not constrained to follow a parametric functional representation.
However, the rate of explant migration is reduced compared to the migration rate predicted by the ABM in the absence of the underpinning intracellular model (compare to Figure 3).
The formulae underpinning the model is given as; Let Y be a dichotomous variable which is defined as Y=left{begin{array}{c}hfill 1kern0.24em forkern0.24em subscribershfill hfill 0kern0.24em forkern0.24em nonmathit{hbox subscribershfill end{array}right.
The assumption underpinning the model was that historical rates of retirement will be reflected in future cohorts.
Since models can be based on conflicting assumptions yet generate patterns seen in the real world, a good 'fit' to empirical data does not in itself vindicate the theory underpinning the model.
The biochemical equations that underpin Model 3 are available as additional files.
Volkswagen is gearing up to launch its MEB platform, which will prove the base of its I.D. line of electric cars, as well as the underpinning of electric models from other brands in the larger Volkswagen Group.
JH contributed to the manuscript editing and developed the population equations underpinning the model.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com