The presence of other congenital malformations or a positive family history should alert the clinician to the possibility of an underlying, possibly genetic cause [ 1, 2].
One may speculate about the underlying mechanisms, one possibility being the lack of a selective evolutionary advantage to acquisition of an anti-apoptotic lesion, given that some of these cells must already have been capable of avoiding apoptosis – perhaps due to their primitive developmental stage.
Here, scientists are often facing limited or even contradicting knowledge about the underlying mechanisms, confined experimental possibilities, large biological variability as well as measurement noise.
In this paper we study an approach to cope with these problems, which is not based on probability theory as the more common approaches like, e.g., expectation maximization, but uses possibility theory as the underlying calculus of a graphical model.
Since earlier report has shown that diabetes-induced endothelial dysfunction was caused by increased ROS [ 5], there would be 2 possibilities as the underlying mechanisms of endothelial protective effect; Nicorandil could inhibit both the expression and activity of NADPH oxidase, a major source of ROS [ 23, 24], leading to the reduction of ROS production.
A bigger version of the existing gap would open up with Mr Bush smiting his enemies and his allies whingeing about the underlying causes of terrorism.A sobering possibility, and one that might yet be avoided.
I understand "The Metamorphosis" is often considered to be about Kafka's relationship to his father, but I'm taken with the possibility that the underlying, perhaps unconscious, inspiration for the figure was less metaphorical than that, and resided in his response to his friend's deformity.
For this study we adopt the same bounding limits used by Lindsay et al. (2010), reflecting the continuity of the underlying geology and recognising the possibility of eruptions taking place outside the current extent of the AVF.
It is, however, an obvious possibility that the underlying biochemical mechanism is the same.
This raises the possibility that the underlying aetiology of disorders associated with the mutation of core cohesin components is different from that associated with the disruption of NIPBL.
