Sentence examples for the underlying liability from inspiring English sources

The estimated heritability of post-challenge survival in Group 1 was 0.42 ± 0.07 on the observed binary scale and 0.58 ± 0.09 on the underlying liability scale, derived from fitting a linear animal model and a sire-dam threshold model, respectively.

They also employed variance in liability explained as an effect size measure, which is similar to our study (but we assume a normal distribution of the underlying liability rather than a logistic distribution).

The binary option estimates SNP effects and variance components on the underlying liability scale.

The model is parameterized in terms of variance components and heritability on the underlying liability scale and can be scaled so that the phenotypic variance is 1.

As with POP 1, these heritabilities were transformed on to the underlying liability scale, and a heritability of ~0.4 was obtained using both models (Table 1).

Of the underlying liability that was specific to the progression of substance use (after initiation had been taken into account), genetic factors were most important in cigarette use and unique environmental factors were most important in marijuana use.

In each model the basic assumption in the CTD that the normally distributed underlying liability to a disease or trait in a population is caused by genetic and environmental factors was met, expressed as equal prevalence in MZ and DZ twin pairs [ 19, 30].

The method takes account of the binary (0-1) nature of case-control data and estimates the genetic variance on the, more interpretable, underlying liability scale.

For a canalized phenotype, which modern usage expands to include nondevelopmental traits, the "zone of canalization" is the range of underlying liability over which potentially disruptive variation may be absorbed without serious consequence to the expressed trait value (L ynch and W alsh 1998).

Furthermore, when incidence approaches extreme values, animals with the most common binary phenotype will be less informative, since their expected (average) underlying liability approaches the family means, while the opposite is true for animals that have the least common binary phenotype.

Endophenotypes refer to quantifiable intermediate constructs that index an underlying liability to a disorder or behavioural trait.