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CoSE algorithm runs in O (k · (| V | 2 + | E | ) ) time, where the underlying compound graph is represented with C = (V, E, F ), and k is the number of iterations needed to converge.
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The purpose of untargeted metabolic profiling in our work was to sample metabolic diversity without bias for the biological activity or practical relevance of the underlying compounds.
To investigate the mechanism underlying Compound K-induced ΔΨ m changes in HL-60 cells, we examined the translocations of cytosolic Bid and Bax into mitochondria after treating cells with Compound K.
Activity cliff-forming compounds give rise to sharp curvatures in the structure-activity relationship surface and thus might suggest that affected groups establish significant pharmacophoric features in an underlying compound class.
This historic book odour wheel is intended to be a inter-disciplinary collaboration tool, used by untrained noses to 'translate' curatorial or conservational concerns about materials degradation into an understanding of the underlying chemical compounds causing it, and informing conservation decisions.
To reveal the underlying mechanisms, we created compounds of intense negative faces combined with positive bodies, and vice versa.
Despite the potential diagnostic value of Cho-containing compounds, the underlying mechanisms causing the alterations in Cho metabolism are not fully understood [ 23].
In secondary assays that investigated the underlying mechanisms of the hit compounds, the authors concentrated on the adenosine analogue NECA (5′-N-ethylcarboxamidoadenosine), the most effective compound.
This issue is further compounded by the underlying hardware.
However, the underlying molecular mechanisms of the compounds listed in this chapter were not elucidated in detail by the respective authors.
Of course, there are some parallels between these classical studies and our experiments, like the focus on GLV compounds; however, the underlying questions differ fundamentally.
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CEO of Professional Science Editing for Scientists @ prosciediting.com