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Clinical neuroimaging and animal studies are only now beginning to shed light on some of the underlying central mechanisms.
Conventional MR imaging techniques still lack specificity for the underlying central nervous system tissue damage in multiple sclerosis (MS), impeding a comprehensive investigation of the key mechanisms responsible for neurological disability such as myelin damage and repair, neurodegeneration and neuroinflammation.
However more work is required to determine the underlying central vascular mechanism/s.
The underlying central mechanisms can be grouped into two major categories: Impaired inhibition and enhanced excitation in nociceptive pathways.
In conclusion, the underlying central mechanisms of esophageal visceral sensation in different types of GERD patients are quite different.
Classical (TCM) acupuncture's attempts to treat the 'root' (the underlying central disharmony) and 'branch' (the specific presenting symptoms) of the patient [ 22, 35].
Similar(53)
The heterogeneity of pain sensitivity within migraineurs suggested that there may be at least two subtypes of episodic migraineurs: one with dysfunction in the pain modulatory system underlying central sensitization and another with more localized pain sensitivity.
Patients who are more prone to delirium, such as the elderly or those with underlying central nervous system disease, also may have heightened central nervous system response to inflammatory mediators.
New streams can be created -- in the West, by Christianity, or Luther, or the Renaissance, or the Romantic movement -- but in the end they derive from a single river, an underlying central tradition, which, sometimes, in radically altered forms, survives.
However, the underlying rationale of central place fractals in the real world has not yet been revealed so far.
In both cases the underlying knowledge becomes a central asset for further exploring the endpoint's mechanism or predicting the behaviour of unseen compounds.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com