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The model considers the uncoupling between nutrients uptake and growth and the possibility of luxurious uptake of nutrients.
The proposed architecture relies in the publisher/subscriber protocol, which is characterized by the uncoupling between its components, anonymous communication with content-based messages, and many-to-many communications.
Glycolytic metabolism explains not only the higher ATP synthesis rate required for cell growth, but also the uncoupling between mitochondrial activity and bioenergetics needed to provide anabolism with sufficient precursors.
The cause of these events is still under debate, but recently it was demonstrated to be mostly due to the uncoupling between primary production and bacterial consumption [34].
This indicates that the glutamate-glutamine cycle by itself suffices to explain part of the uncoupling between glucose and oxygen utilization.
We find that the velocity of the glutamate-glutamine cycle (Vcyc) explains part of the uncoupling between glucose and oxygen utilization at increasing Vcyc levels.
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The lack of shared axial patterning mechanisms (Hox and Cdx) across the two life stages may help explain the extreme morphogenetic uncoupling between the larva and the juvenile.
We found that the degree of uncoupling between the transcriptome and the translatome was higher than the degree of coupling, both in terms of single transcripts undergoing changes in levels and in terms of the ontological enrichment of the corresponding proteins.
Our data cannot conclusively address this point, because the currently available experimental paradigms do not allow the requisite uncoupling between cilia and flow.
Therefore, this broad analysis confirmed that the marked uncoupling between transcriptome and translatome profiles is a feature far from being confined to short-time treatment of HeLa cells with EGF, assuming instead the dimension of a general principle describing change of gene expression in mammals.
Finally, our results defining regulation of overall size of clathrin-coated buds raise the possibility that kinetic uncoupling between the outer and inner layer components of other vesicular coats could also alter the morphology of the forming tubulovesiclular carrier to accommodate variably sized cargo.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com