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During reversals, the two machineries switch polarity synchronously.
The initiation of replication usually represses transcription (1) to prevent the collision of the two machineries (2).
Would it be possible that the two machineries – for DNA replication and for protein turnover – communicate with each other, with each of them relying on the other?
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Caspase-3 can be activated through two machineries, namely the mitochondria-related apoptosis protease-activating factor-1/caspase-9/caspase-3 cascade, and Fas-associated adapter protein/caspase-8/caspase-3 cascade which is the extrinsic apoptotic pathway [ 57].
For instance, in the case of the EGF receptor (EGFR) that is under intensive investigation, two machineries for internalization have been proposed [3].
That has been demonstrated in the case of the silent human provirus HERV-K18, where AS transcription promotes S transcription [41], as well as in a variety of other cases, where AS transcription conversely inhibits S transcription, because of competition between the two transcriptional machineries for shared cofactors, or due to collision between them [42].
DNA replication involves two machineries, DnaE and PolC.
Thus, osteoclasts use at least two machineries for cell-cell interaction during in vitro secondary fusion.
Hamdi owns two machinery workshops, one in the town of Minyat Sammanoud, another in Kuwait, where he lives full time.
In particular, we focus on the ubiquitin-proteasome machinery and the autophagy-lysosome machinery, the two most important cell proteolytic systems that control protein turnover in muscle.
I think there are, actually, many points of agreement with respect to the evolution of many complex features of life, including the two distinct DNA replication machineries (archaeal and bacterial) within a precellular genetic pool (see our paper with Bill Martin on this subject, ref. 95).
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