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Many of the tested compounds were potent and/or selective against one of the two isoforms of HO.
The average interaction energies of the peptide with the two isoforms of cyclooxygenase (COX) were of the same order (−122.8 and −126 kcal/mol).
No changes in GAD65 expression, one of the two isoforms of GAD, were detected in the striatum, which further validates the specificity of the siRNA.
The two isoforms of this enzyme, MAO-A and -B, are considered to be drug targets for the therapy of depression and neurodegenerative diseases, respectively.
Here, we examined the localization and function of the two isoforms of zebrafish Pcdh15a (CD1 and CD3) in pcdh15a-null mutants by assessing Pcdh15a transgene-mediated rescue of auditory/vestibular behavior and hair cell morphology and activity.
Fig. 1 Western blot analyses of the two isoforms of the myosin heavy chain.
RpiB, one of the two isoforms of Rpi, is also a potential drug target for some pathogenic bacteria.
Different immune cells have shown differential expression of the two isoforms of OPN: secreted form of OPN (sOPN) and intracellular form of OPN (iOPN).
Expression of chimeras between the two isoforms of ankyrin suggests that the membrane-binding domain of ankyrin-G is critical for reducing the Ina-p of Nav1.6.
No functional difference has been described between the two isoforms of MeCP2, MeCP2A and MeCP2B.
These results suggest that the two isoforms of MBD5 are indeed expressed in cultured cells.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com