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In this canine model, surgically applied damage to the articular cartilage of the weight-bearing areas of the femoral condyles, not damaging the subchondral bone, is the trigger for development of OA features [ 22].
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It is possible that Matrigel is required for the engraftment of H2BGFP+/CD24+/CD29lo cells in vivo, but based on our data, we conclude that pregnancy is still the critical trigger for development of mammary structures able to pass the threshold of detection in most outgrowths.
Injury could be the trigger for the development of this special type of secondary syphilitic cutaneous manifestation.
These observations raise the possibility that acute LBP can be a trigger for development of chronic discogenic LBP.
A high computational cost of a systematic search over a predefined set of parameters' values is a trigger for development of new optimization algorithms.
In these patients, pathogenic infection may provide an antigenic trigger for development of loss of self-tolerance [ 46].
The commonly reported presence of physical precipitating factors at onset such as injury could provide a relevant trigger for development of a 'conversion motor representation'.
The trigger for the development of a new analysis tool was our need for 'on-the-fly' structure finding in the astrophysical simulation code (Teyssier 2002), in order to locate gas and/or dark matter clumps while the simulation is running.
Additionally, the expected CO2 levels at the inner and outer cortex were around 0.7%and1.1%1%, respectively (data not shown), suggesting that CO2 was not the trigger for the development of the disorder.
Further research to elucidate the triggers for the development of disease in this high risk young population in particular is clearly warranted.
Rather than becoming technically feasible, however, the trigger for innovation development here is the viability of its realization.
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