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Most of the trials, often sponsored by drug companies or medical device makers, involve pets with cancer — a leading natural cause of death in older dogs — in which the animals receive groundbreaking drugs or other treatments that are eventually meant for people.
The anti-diabetes interventions used in the trials often included add-on regimens consisting of several oral drugs.
Two of the arguments called to critically discuss this evidence can be cited: (i) the single studies were not designed and powered to primarily address DM as an endpoint and maximum follow-up did not exceed 5 years; (ii) the definition of DM varied among the trials, often derived from non-standardized criteria, and new-onset DM was usually not rigorously screened for.
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Dede's parents attended the trial, often leaving the packed courtroom during emotional testimony.
By American standards, the trial often had a circuslike atmosphere, with protracted quarrels between screaming lawyers playing to the raucous crowds that daily packed a theater in Les Cayes, Haiti's third-largest city.
They sat through the trial, often in tears, but more often than not resolute and dignified.
There is an ethical requirement to obtain informed consent from potential participants before they are enrolled in a randomised controlled trial (RCT). 1 2 As part of the informed consent process, potential trial participants are provided with written information about the trial often in the form of a participant information leaflet (PIL).
When formalized, this role is commonly performed by a multi-disciplinary group of specialist, often referred to as a Data Monitoring Committee (DMC), which makes recommendations to those in charge of the overall management of the trial, often referred to as the Trial Steering Committee TSCC).
Nonetheless, in terms of extrapolation of findings regarding the intervention itself, these trials often have poor generalizability [ 9].
The Nuremberg trials, often viewed as the pinnacle of legalism, were, nevertheless, based on ex post facto charges (see Bass 2002: Ch. 5).
Most trials consisted of one active and one control arm, but the drug trials often had active arms at several doses and 8/28 (29%) had no placebo arm.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com