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The stage at which the trial stops— M say is a random variable.
If less than 7 patients have clinical benefit the trial stops, if more than 7 patients have clinical benefit a total of 40 patients will be included.
Successive patients are treated at doses recommended by the updated model until the trial stops, typically after a pre-defined maximum number of patients.
We refer to this approach as unconditional because, in a three-stage trial, for example, it produces an estimate of the treatment effect regardless of whether the trial stops at stage one, two, or three and it is therefore unbiased by definition when one averages across all possible realizations of the sequential trial.
It will be denoted by Π ^ p. To provide an estimate when the trial stops at the first stage, several choices are possible, and we decided to use the first stage sample proportion X1/ n1, which is equal to the UMVUE in this case.
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In much of Egypt itself, the trial stopped many daily routines.
If it was known after the first year that the gel was working, why wasn't the trial stopped?
The trial stopped on Thursday without a conclusion.
Meanwhile Kenyan and African leaders have instituted a campaign to have the trial stopped.
The trial stopped recruiting on the 14th November 2002.
The author of one trial informed us that the trial stopped early for benefit [ 26].
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