Exact(10)
For example, the translocation between chromosomes 9 and 22 (Philadelphia chromosome) (Nowell and Hungerford, 1960; Rowley, 1973) led to identification of the BCR/ABL1 gene fusion (de Klein et al., 1982), which is created at the join between the two chromosomes and is now used for highly successfully targeted therapy in chronic myeloid leukemia.
The MEN_MER population bears two normal chromosomal sets with one set including the translocation between the 1st and 3rd chromosomes.
The tandem duplication on chromosome 17 and the translocation between chromosome 17 and chromosome 11 were confirmed structural variations detected only in the mutant individuals.
Both species, with other grasshopper species, share the same mitochondrial genome organization, which differs from that of the available ensiferan species by the translocation between trnD and trnK.
The molecular hallmark of CML, BCR/ABL fusion oncogene, resulting from the translocation between chromosomes 9 and 22, has a critical role in the pathogenesis of CML.
Approximately 12%% of childhood AML cases bear the translocation between chromosomes 8 and 21 resulting in AML1/ETO (RUNX1/CBfusion fusion gene.
Similar(50)
The translocations between diverged sequences are rare in Saccharomyces yeast as described above.
The major disadvantage of these populations is the large translocation between the top of Gifu chromosome 1 and the bottom of MG-20 chromosome 2, which corresponds to a genomic region with complete suppression of recombination.
The inefficient translocation between the exonuclease and polymerase active sites in conjunction with the nonprocessive nature of the exonuclease raised the possibility that UL30 might contain at least partially independent DNA binding domains for the polymerase and exonuclease active sites.
The (8 21) translocation between the AML1 and ETO genes is seen in approximately 12 15% of all acute myeloid leukemia (AML) and is a frequently observed nonrandom genetic alteration associated with AML.
The translocation breakpoint between Chr. 02 and Chr.
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