The translation, folding, processing, and function of these viral proteins depend on a specific intracellular structure in the hepatocytes called a membranous web, which also hosts viral RNA replication to generate new HCV genomes and assists in the assembly of new infectious viral particles (Chao et al. 2012).
These results may shed light on the therapeutic strategies in septic shock patients, though further studies including in vivo studies are needed to define the detailed pathways as well as regulations at the translation and protein-function levels in mediation of astrocyte death.
Previous studies have demonstrated a role for local translation in altering the structure and function of synapses during synapse formation and experience-dependent synaptic plasticity.
On the basis of the one-dimension infinite element theory, the coordinate translation and shape function of 3D point-radiate 8-node and 4-node infinite elements are derived.
These differences may have profound effects on translation, as well as the isoform and function of the protein produced.
It is reasonable to think that the evolution could be playing with these semi-independent features (amino acid type and translation speed) to obtain the final structure and function of the protein.
There appears to be good correlation in genes that are identified as being involved in both the GO process of "translation" and GO function of "structural constituent of ribosome", with a ROC area of 0.92 when trying to predict the function of these genes.
We, therefore, performed simulations of the noncanonical pathway coupling by systematically varying the translation delay function of TRAF1.
At present various options are under consideration: (a) direct modulation of the transporter by specific inhibitors, (b) interference with the regulatory cascade of protein transcription, translation and function, and (c) encapsulation of substrates into delivery systems, which are able to by-pass p-glycoprotein.
Although the compensatory mechanism may improve the efficiency of the mitochondrial translation, the function of the OXPHOS system can still remain impaired in cell with mtDNA mutations.
