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The first variable is a positive integer, which is a relative measure of the contribution of that particular flux to the total pathway.
To address this question, we defined the Total Pathway Connectivity (P T ) for each of the 128 annotated pathways in our ensemble graph as the sum of all degrees (K) for genes included in a pathway.
The Total Pathway Connectivity (P T ) is defined as the sum of all pathway gene degrees (K); For n total genes associated with pathway i. Edges comprising the Total Pathway Connectivity (P T ) can be divided into Internal (P IN ) vs. External (P EX ), defined as edges which connect 2 genes within a pathway vs. edges which connect a gene within the pathway to a gene outside of the pathway.
The creation of cluster like this one can be due also because the VOCs that the EN is able to detect were present in the total pathway of the LAB and to the similarity of the colonies because of the same provenience of the samples, all them indigenous contaminated of the chicken meat.
[The chemical-by-pathway assay LEC values are given in Supplemental Material, Table 3 (doi:10.1289/ehp.0901392).] This collection of published pathways show significant overlap, so we also compiled a minimal set of 33 pathways inclusive of all genes represented in the total pathway set.
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Finally, 488, 456, and 855 (14%, 15%, and 12% of the total) pathways from Biocarta, KEGG, and Reactome pathway databases, respectively, were found to be significant across 16 types of cancers, and used for further analysis.
The length of total pathway was measured over seven different temporal length scales (step lengths), ranging from one day to one week, and a seasonal mean was calculated.
A Sobel test was used on the data, where pathway c' represents the direct effect after controlling for the mediator, and pathway ab represents the total indirect pathway of the mediator (see Fig. 3).
Pathway Modularity (M) is defined based on the ratio of internal to total pathway edges (PIN/ P T ) compared to what would be expected by chance, given a completely random association of genes to pathways.
One major deficiency in understanding such conditions is the paucity of information regarding the total metabolic pathway for various amino acids that may be implicated in their causation.
However, given the importance of troponin in the diagnosis of myocardial infarction, implementing this test requires rigorous analytical and clinical verification across the total testing pathway.
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