The silk holds each device in place, even after the array is implanted in an animal and wetted with saline, causing it to conform to the tissue surface.
"Silk is mechanically strong enough to act as a support, but if you pour water on it, it conforms to the tissue surface," says Omenetto.
The puncture force generated at the mutation point where the tissue surface was breached.
The bowel is large, delicate, flexible, and has a natural lubricant on the tissue surface.
For bacteria to effectively penetrate the mucus layer and infect the tissues below, they need to form clusters that can adhere to the tissue surface.
The adaptive focusing mechanism was demonstrated to enable acquisition of in-focus images even when the probe was not centered and the tissue surface was irregular.
The sub-lethal coral disease response extended directly from the disease front suggesting that pathogenesis is highly localized, potentially spreading across the tissue surface, which can be tested in future studies.
A non-porous platen was brought into contact with the tissue surface, and the tissue was compressed to 20% strain at 2 mm/s (human walking) with a 10 N load held for 5 minutes.
We normalized counts of zooxanthellae by dividing numbers of each of Symbiodinium by contour length (i.e., number of Symbiodinium per unit length of tissue) for each health state and location within the tissue (surface or basal body wall).
Immunostained thick femoral slices were successively washed in PBS overnight and incubated in RapiClear 1.52, for a minimum of 6 h, which typically increased imaging depth to 150 µm from the tissue surface without significant loss of signal intensity.
Fresh esophageal and gastric epithelium taken from rats were imaged with OCM a few micrometers below the tissue surface.
