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In theory, by the time term policyholders reach their 50s and 60s, they'll no longer need their policies because their investment portfolios will have ballooned to such a massive size that they will be wealthy enough to self-insure in the event of their death.
*To compute effect estimates from longitudinal models, the time term was fixed at zero.
Since time trend is explicitly addressed by adding the time term in the generalised additive models, we used the daily number of deaths, instead of the year-adjusted mortality rate.
Every 1°C increase in daily mean temperature showed a 0.60% increase (95% Confidence interval (CI): 0.53%, 0.66%) in EDV, and a 1.25% increase (95% CI: 0.97%, 1.53%) in EAD (plots of the time term in statistical model equation 2 were provided in Additional file 1: Figure S3).
Figure 3 shows the exposure-response relationship between daily mean temperature and EDV and EAD at the same day as event (lag0), after controlling for confounders in the models (plots of the time term in statistical model equation 1 were provided in Additional file 1: Figure S2).
Interestingly, while there is a linear component to this relationship (P = 3.6 × 10−8), recombination frequency appears to increase quadratically across treatments and indeed, the time term in our linear model (see Materials and Methods) also significantly contributes to the variation in recombination frequency observed in this experiment (P = 0.021).
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The newspapers of the time termed this phenomenon "Klondicitis".
Along with the fixed linear and quadratic terms for time, a random subject-specific intercept, and an initial covariance set at Compound Symmetry (CS), each fixed factor was tested independently, with or without its interaction with the time terms.
Speaking of Geithner, the Times has a massive front-page story today focussing on his work at the New York Fed, and his close ties to what the Times terms "the finance club".
The time-term factors along the profile are shown in Fig. 6(b).
The static correction factor, which eliminates the travel time through the surface layer, can be calculated from the time-term factor.
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