The –(CO)–CH2 COOR side chain at the fifth position as in candidate VIII, the methyl amino group at the second position, and the ester at the third position of the thiophene can be considered as a three-point pharmacophore for designing better anti-inflammatory agents.
If you do not believe (as he does) that the success of Danish non-violent resistance to Nazism shows that the second world war was the wrong way to defeat Hitler, then you are not just wrong, you are bloodthirsty, ignorant and stupid.He blithely ignores the third position of the reluctant warrior, who takes up arms only when all else has failed, sombrely aware of the ghastly mess that will ensue.
Especially authors, place education in the third position of the most frequent keywords and entrepreneurship education in the 14th.
A practical consequence of redundancy is that errors in the third position of the triplet codon cause only a silent mutation or an error that would not affect the protein because the hydrophilicity or hydrophobicity is maintained by equivalent substitution of amino acids; for example, a codon of NUN (where N = any nucleotide) tends to code for hydrophobic amino acids.
Note in the table, below, eight amino acids are not affected at all by mutations at the third position of the codon, whereas in the figure above, a mutation at the second position is likely to cause a radical change in the physicochemical properties of the encoded amino acid.
Typically, proline on the third position of the Gly-X-Pro repeat is hydroxylated [49], and lysine within the consensus GXKG(E/D) is hydroxylated and glycosylated with α-1,2-glucosyl-galactosyl disaccharide moieties [40], [50], [51].
At the same time, the incorporation of M2 sequence into the third position of the recombinant molecule did not result in any overt cytotoxicity in vitro, different from full-size M2 (Fig. 3).
A clear preference for A2pm at the third position of the peptide had already been observed with EcMpl, although to a lesser extent (kcat values of the E. coli enzyme for these two tripeptides were 16 min−1 and 290 min−1, respectively) [13].
The third position of the acceptor stem corresponds to the third position of the anticodon that, in turn, corresponds to the first position of codons, which is important for further, more specific, coding.
Secondly, a SNP (rs72558377) is located in the target site corresponding to the third position of the miRNA seed.
L. fermentum has an L-ornithine substituted for L-lysine at the third position of the tetrapeptide.
