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We demonstrate that the sole assessment of therapy effects by apoptosis imaging can be misleading, depending on the therapy effect on the tumor vasculature.
Author׳s group is carrying out development of BNCT-SPECT with CdTe device, which monitors the therapy effect of BNCT in real-time.
The mechanism of the therapy effect is the synergy of an enhanced accumulation of osteotropic agents on the metastatic lesion and the energy deposit by particle radiation (β −, inner conversion or α-particles).
Blinding will be used both for the evaluators and the patients to avoid measurement bias and the influence of psychological factors on the therapy effect.
In this study, we confirmed that the plasma concentration of SDF-1 isignificantlyly correlated with the therapy effect for CAP patients.
Therefore, neovasculature imaging is essential to assess tumor behavior, forecasting the treatment response, changing the therapy strategy if necessary, and ultimately maximizing the therapy effect.
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Magnetically-drug targeting effects might also promote the drug accumulation in targeted tumor site under magnetic field guidance which further increase the therapy effects of the drug for inhibiting cancer proliferation.
FLT had, compared with ACE, CHO, MET and FDG, higher sensitivity in monitoring the therapy effects.
All therapy effects will first be estimated using the intention-to-treat principle, supplemented by estimation of the therapy effects in those participants who actually receive the intervention via estimation of the Complier-Average Causal effect or CACE [ 47, 48].
Sample size calculations were performed with G*Power 3.1.3 (Düsseldorf, Germany) based on the therapy effects on pain in the pilot study of Moseley [ 29], and accounting for a 30% loss to follow-up after 1 year.
To help compare the therapy effects on different endpoints, changes in initial concentrations of zymogens or inhibitors and increasing initial concentrations of active molecules on TGA parameters and aPTT are summarized in four categories in Table 1.
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