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The AUC was determined by trapezoidal integration up to the time of the last serum samples, and the terminal component was estimated using the fitted half-life.
COX11 is a nuclear encoded mitochondrial protein and the terminal component of the mitochondrial respiratory chain.
Thus, during hypothermia, the concentration of activation products was reduced, including TCC, the terminal component of complement activation.
Cox7b encodes cytochrome C oxidase, subunit VIIb which is the terminal component of the mitochondrial respiratory chain and catalyzes the electron transfer from reduced cytochrome C to oxygen.
Complex IV is the terminal component of the respiratory chain, in which electrons received from cytochrome c reduce molecular oxygen to water and protons are pumped into the intermembrane space.
In this multi-step enzymatic process, oxygen serves as the final electron acceptor for cytochrome c oxidase, the terminal component of the mitochondrial enzymatic complex that catalyzes the four-electron reduction of O2 to H2O.
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CFHR1 is a complement regulator that blocks C5 convertase activity as well as assembly and membrane insertion of the terminal components [20].
Note that these TFs are not regulators but the terminal components of the pathways.
Hsfs are the terminal components of a signal transduction chain mediating the activation of genes responsive to heat or other stress stimuli [ 3, 4].
Genes within the chitin biosynthesis pathway in T. hominis are generally expressed at similar levels in our analysis (600 900 fpkm), however expression of the terminal components of the pathway, chitinase and chitin synthases, were much lower (20 30fpkm) (Fig. 4).
Recurrent meningococcal infections (meningitis/sepsis) are very suggestive of deficiencies of the terminal components of the complement system (C5 C9) and warrant screening of the classical (CH50) and alternative (AP50) complement pathways.
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