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Results show that the targeted method of discrete element model is more applicable and precise than embedded element method in which the perfect bond with no slip is dominant between the materials.
Wild-type samples were used to validate the targeted method.
In our previous work, the same serum samples were profiled using an untargeted gas chromatography mass spectrometry platform, which provided a broader coverage of the metabolome than the targeted method used here.
Chemical screens, such as the targeted method used in the Ramakrishnan Mycobacterium studies, can be employed on a larger scale to look for suppressors or enhancers of a given phenotype.
The "targeted" method consisted of a 20 μm diameter illumination area and a detector that captured all emission photons exiting the surface of the tissue.
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After the characterization, a targeted method for the analysis of the six detected peptides was designed.
The method's efficiencies come from providing a targeted method for finding the best level of data aggregation and so avoiding the aggregation of subspaces where no outbreak is occurring.
To design our SRM assay, we adopted an iterative method development strategy, eliminating poor performing transitions from the SRM assay in a targeted method refinement cycle [ 23].
In general, two main proteomics tracks can be undertaken, the "shotgun" or "bottom-up" methods and the targeted proteomics methods.
Preliminary results show that the targeted QSPR method yields predictions within the experimental error level for compounds well represented in the database and fairly accurate estimates for complex compounds that are sparsely represented.
Compound concentrations were calculated using the "targeted profiling" method (see [ 17] for more information).
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