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Although the targeted effects of sunitinib are against receptor tyrosine kinases, the off-target effects of the drug are unclear and pre-clinical work shows that apoptosis does occur (Xin et al, 2009).
We successfully delivered the oligos into the nucleus, resulting in the targeted effects.
In the previous issue of Breast Cancer Research, Han and colleagues investigated the targeted effects of GSI-I [ 1].
Similar to those of A-729611, the targeted effects of FLB-12 are PXR-specific, with no effects on other orphan nuclear receptors [ 77].
It is anticipated that future studies of COI of stomach cancer to include the targeted effects of new cancer control programs to enable prioritizing implementation of new policies and the development of medical technologies.
Current widespread use of shRNA as a means to perturb specific redox couples may be misinterpreted if the targeted effects are not monitored in the context of potential global remodeling of the redox enzyme network.
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That's why I'm also proud of the fact that the government has made huge progress in tackling pensioner poverty - the Tory legacy was 2.7 million pensioners living in poverty in 1997; that's now down to 1.8 million, mainly due to the targeted effect of Labour's pension credit.
The targeted effect-site concentrations (Ce) of propofol and remifentanil for induction were 3 μg/ml and 2.5 ng/ml, respectively.
To assess the sensitivity of the dose response profile due to the specification of the priors, the posteriors were recomputed under the alternative priors for PASI75 responses, and the resulted dose selection based on the probability to achieve the targeted effect for PASI75 were evaluated.
Like their targeted effects, the global activity of the histone-modifying enzymes can modulate gene activity (Vogelauer et al, 2000).
In addition to investigating the selective antiproliferation effects of mc-oriP-IFNγ in vitro, the targeted antitumor effects of mc-oriP-IFNγ were assessed in NPC-xenografts.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com