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In this case, a resistance phenotype likely indicates the target of the compound.
One hit was active in zebrafish embryos and zebrafish cell culture, but not in mammalian cell culture, suggesting the target of the compound was specific to the zebrafish and not conserved in mammalian cells.
The CBP KIX domain may also be the target of the compound ICG-001 (see Figure 18), which appears to block the association of CBP with β-catenin, and decrease expression of genes usually induced in the Wnt/β-catenin/CBP pathway.
Similar(57)
This suggests that the concentrations used in the metabolic studies are within the range of the intracellular concentration of the compound, and that the pathways for synthesis of PC from both choline and ethanolamine are the targets of the compound.
Top screen hits included shRNAs targeting dihydrofolate reductase (DHFR), the target of the anti-inflammatory compound methotrexate.
The target of the strike was a compound in the Mamad Khel area of North Waziristan, the officials said.
The target of the attack on Sunday was a compound in the town of Mir Ali.
Erg11p is the target of the azole family of anti-fungal compounds.
Straightforward applications of the concept of chemical similarity (28), they search the BindingDB dataset for compounds similar to a query compound, and suggest the targets of these compounds as potential targets of the query compound.
The targets of the attacks were compounds and militants' positions in the mountains west of Miram Shah, the capital of North Waziristan.
The possible target of the compound was determined by docking analysis.
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