In the present article, we have reported the design, synthesis, and identification of highly potent benzhydrol derivatives as squalene synthase inhibitors (compound 1).
The pharmacological evaluation, synthesis and identification of the 16 enantiomers were completed in Prof. Liang Huang׳s laboratory (Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China).
The synthesis, isolation and identification of C3v- 1911C64H4, as described in this work, show that this combustion method is successful, is energy efficient and is a promising candidate for the macroscopic synthesis of non-IPR fullerenes.
Nevertheless, we envision that with further progress in the development of nanofiber synthesis strategies and identification of "killer" applications of nanofibers, nanofiber technology will mature and move beyond its current state towards commercial realization and applications.
In this report we disclose the synthesis, vasodilatory activity, and identification of bioactive conformation of new N-acylhydrazone and N-methyl-N-acylhydrazone derivatives, structurally designed by bioisosteric replacements of previously described cardioactive compounds LASSBio-294 and its N-methyl derivative LASSBio-785.
We report here the synthesis, high-throughput screening, and identification of novel CP ligands against HIV-1 CA. The most promising peptides (CP2 and CP4) bound with ∼500 nM affinity and inhibited the LysRS/CA interaction with IC50 values of ∼1 μM in vitro.
The next step of the potent safe anti-inflammatory drug identification involves the synthesis and biological evaluation of the selected molecules which are in progress.
Here, we report the library synthesis, high-throughput screening, and identification of cyclic peptides (CPs) that bind HIV-1 CA. Scrambling or single-residue changes of the selected peptide sequences eliminated binding, suggesting a sequence-specific mode of interaction.
Accurate vocal tract models become increasingly important for the investigation of speech analysis, synthesis and identification.
It was shown that the synthesis and calcinations procedures hinder the crystallographic identification of the presence of alumina.
