Exact(2)
To extend our investigation of the sustained role of Bcd in transcriptional decisions of its target genes, we analyzed Bcd intensities at the detected intron dot sites.
As shown in a recent study [31], embryos at nuclear cycle 14, unlike those at earlier stages, exhibit a more stochastic pattern in Bcd target gene transcription, a feature that makes this stage particularly useful for investigating the sustained role of Bcd in transcriptional decisions.
Similar(58)
Such information is essential for evaluating the controversial question of whether Bcd plays a transient or sustained role in the transcriptional decisions of its target genes to generate sharp expression boundaries during development.
Even as sales continue to grow, it is yet to be seen whether the mobile phone will play a significant, sustained role in alleviating poverty in the developing world.
Firstly, empowering all community stakeholders for effective involvement (QC2) is essential if each is to play a meaningful and sustained role in the programmes being implemented.
These results underscore a sustained role of Bcd in the transcriptional decisions of its target genes as embryonic development progresses.
For example, it remains controversial whether the Drosophila morphogenetic protein Bicoid (Bcd) plays a transient or sustained role in activating its target genes to establish sharp expression boundaries during development.
Now there is an opportunity and a need for a more sustained role.
It establishes a sustained role of Bcd in transcriptional decisions of individual copies of its target genes to generate sharp expression boundaries.
Chondrocyte derived S100A8 and S100A9 may have a sustained role in cartilage degradation in inflammatory arthritis.
It is likely that other BTB proteins, while not examined in the current study, play early or sustained roles in ongoing BTB dysfunction.
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