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For instance, a placebo-controlled intervention study conducted in 916 children from the Netherlands reported that TLR2 variants influenced the susceptibility of developing asthma in response to NO2 and PM2.5 exposure (Kerkhof et al. 2010).
Therefore, in a murine, resuscitated cecal ligation and puncture-induced septic shock, we tested the hypothesis whether a transient hyperglycemia in vivo would downregulate CSE expression, affect mitochondrial function, and increase the susceptibility of developing hepatic steatosis.
Based on these findings, we conclude that NLR increase could serve as a matrix for monitoring the susceptibility of developing VTEs after knee arthroplasty and prior to hospital discharge.
It has also been suggested that corneal biomechanical properties may reflect globe biomechanics and thus give an indication of the susceptibility of developing glaucomatous damage [ 6, 7].
Here, we showed that a common genetic variant within NDUFC2 altered the susceptibility of developing T2DM only in combination with a certain mtDNA genetic background (haplogroup cluster HV).
In summary, the present study suggests that genetic variation in the HSPA1L and HSPA1B genes may influence the susceptibility of developing IPF in our population.
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Older age, not having at least one parent who is a health care professional, having had a personal, familiar, or friendly history of cervical cancer, and need of additional information about this cancer and HPV vaccination were significantly the predictors of the perceived susceptibility of developing cervical cancer (Model 2 in Table 2).
As for c.1517G>C, the CC genotype was statistically associated with the increased susceptibility of developing HCC compared to GG genotype and GC/GG carriers (all P < 0.001).
As for c.1254C>T, the TT genotype was statistically associated with the increased susceptibility of developing HCC compared to CC genotype and CT/CC carriers (all P < 0.001).
Older age, not having a parent who is a health care professional, having had a personal, familiar, or friendly history of cervical cancer, and need of additional information were predictors of the perceived susceptibility of developing cervical cancer.
This study is to be considered as a preliminary 'good start', and further investigations are required to elucidate the exact mechanisms behind the association of the ACE I/D polymorphism and susceptibility of developing pterygium in the peculiar Sardinian population.
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