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Alternatively, the subtle increase in HIF-alpha proteins at this time point may reflect hypoxia-independent mechanisms of HIF stabilisation by reactive oxygen species [36] or cytokines [8].
These data indicate that the subtle increase of lysosomal pH induced by vacuolin-1 does not affect lysosomal protease activity.
As such, cytotoxic effects may account for the subtle increase in GFP signal in dsNanog-82 and dsNanog-205 transfected cells.
Thus, the subtle increase in ADH precursor level in CAP patients with hyponatremia is likely due to a stress response which overrules the osmoregulatory function.
The subtle increase in elevation in the case of GlcNAcβ may be accounted for by the equatorial configuration at C1, which tends to place the monosaccharide ring further from the surface, compared with the axial configuration.
Overall, our results together with evidence from literature indicate that the subtle increase in circulating leukocytes seems the most consistent effect of an inflammatory response after the OGTT and OG + LTT challenge.
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The addition of the meditational relaxation component of LY may also be responsible for the subtle increases in happiness, mood and optimism and the subtle decreases in stress.
Moreover, the subtle increases in vascular markers such as sICAM-1 and sVCAM-1 after the OG + LTT challenge are of limited value, because they only became apparent in comparison to the water control challenge which has proved to be essential to control for factors such as diurnal variation, prolonged fasting, and sampling procedure.
Concluding, the positive correlation of miR-181c with these two tumor suppressor genes can potentially explain the inhibitory effect of miR-181c on cell growth and the more subtle increase in apoptosis observed in the glioma cells (Figure8).
Furthermore, when these Neo/Null;Fgf8het compound mutants are compared with the Neo/Null;Fgf8wt, we noted a subtle increase in the width of the midface, a lateral pivot of the nasal pit toward the maxilla, and an increase in both the size and width of the nasal pit (Fig. 6C, lower images).
The HTGC and NMR results showed that the saturated fraction is not affected during the thermal stress process, whereas a subtle increase in the number of aromatic compounds was observed as a function of degradation time.
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