The genetic background represents the substrate to the common immune processes involved in psoriasis and IBD.
At times a fairly vulgar Nietzschean, he insisted that the substrate of our common reality, however we might suppress it, was cruelty.
It seems that the presence of disordered regions in the substrate is a common characteristic in the chaperone-substrate complex of T3SS.
Both proteins have some substrates in common with caspase-3, and both are involved in the regulation of nuclear changes during apoptosis, including nuclear lamina breakdown [9], [23].
Of these MMPs, MMP2 and MMP14 may have substrates in common with MMP13, for example, both are also collagenases in vivo [3].
These chaperones are characterized by a promiscuous substrate binding and have many substrates in common (Gong et al. 2009).
A key candidate is MMP9, which has been shown to have several substrates in common with plasmin, including fibrin (Lelongt et al., 2001).
It is well documented that, besides having substrates in common, plasmin and MMP9 are both active following pathophysiological events, such as cancer invasion and wound healing (Green et al., 2008; Hattori et al., 2009), in which they are likely to have both distinct and overlapping functions.
We could clarify that the TCS response regulator AraC was used in the substrate recognition system common to both xylan and galactomannan.
Control of device to device uniformity over the area of the substrate is a common challenge in these solution-processible small molecules that have a strong tendency to crystallize.
The substrate showed a common unbinding pathway in a majority of the simulations, suggesting the functional relevance of this pathway.
