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Staff members for two American senators, one Democrat and one Republican, said all was not lost, however, despite the substantial setback.
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Still, for all of the applause in Washington and London and the very substantial setback the loss of the city represents for the Taliban, its conquest is not a knockout blow.
The judgment is a substantial setback for the prime minister, Theresa May, who wants to set the exit process in motion by March.
Last year the law suffered its first substantial setback when state courts upheld the positions of Glastonbury, Newtown and Bridgewater against developers.
During that period, there was only one substantial setback to the trend, in 1952 and 1953, when the end of the Korean War brought soldiers back to the civilian economy.
"This could represent a substantial setback to their program," David Albright, president of the Institute for Science and International Security, a private group in Washington that tracks nuclear proliferation, said of the problem behind the Bushehr upset.
"That was a substantial setback for Vitro and a substantial victory for the holdouts".
Always adjust your answers to give you the best chance of avoiding the red pitfall arrows as they will otherwise result in a substantial setback.
Fibrosis poses a substantial setback in regenerative medicine.
After an elaborate planning, even an extensive drug testing program can be executed without substantial setbacks.
Yet there have been substantial setbacks.
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CEO of Professional Science Editing for Scientists @ prosciediting.com