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This has always been a paradoxical finding given the substantial sequence conservation between these proteins [4].
Also the substantial sequence differences often seen in the shared effectors may also confer differences between typical and atypical EPEC.
Given the substantial sequence divergence of MYB-related genes, their identification should be careful manual checking.
This finding coupled with the substantial sequence and structural homology between SufB and SufD suggests that sufD results from a duplication of sufB.
However, because of the substantial sequence differences between the two receptors, RHO-based MC4R models are not sufficiently accurate to provide reliable per-residue data regarding function.
The substantial sequence differences between these alternate peptides suggest that they either bind different receptors, or if they interact with the same receptor, they do so with different affinities and/or binding sites.
Similar(53)
Despite the substantial sequencing effort for amplicons, no sequences belonging to the Methanobacteriales order were recovered from this approach.
To remove any batch effects due to the substantial sequencing depth differences between the RNA-Seq and AmpliSeq libraries, we used the removeBatchEffect function from the R/Bioconductor package limma [ 39].
Therefore cross-species (heterologous) microarray studies using gDNA-based probe selection allows the profiling of up to ~58% of the total Musa genome despite the absence of substantial sequence data for this species and the large phylogenetic distance from the target species.
It is highly unlikely that the only portion of the protein with substantial sequence identity between Kir's and KcsA and that determines the selectivity of the channels for potassium would have entirely different structures and/or exist in different locations in these two proteins.
Prima facie, we were confident that regions of difference identified by multiple contiguous probes indeed represented genuine phenomena and demonstrated the presence of substantial sequence differences between S. coelicolor and the S. lividans strains.
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