Sentence examples for the substantial problem from inspiring English sources

"They're unaware of the substantial problem we do have.

Unlike micro-hydro, natural gas, biogas, biomass and other possibilities for off-grid power generation, the substantial problem of temporal inequalities of power supply and demand is attached to wind and solar energy.

Combining FDA-approved drugs with known polyphenolic compounds such as rottlerin, genistein, quercetin, curcumin, and resveratrol may provide novel therapeutic strategies in the treatment of cancer to combat the substantial problem of drug resistance in cancer therapy.

Despite the substantial problems identified, the team was disbanded.

The substantial problems of "explosion of complexity" and "dimension curse" existed in the traditional backstepping technique are circumvented, and it is convenient to implement in applications.

Coupling existing large-scale bottom-up and top-down models [46]; Böhringer and Rutherford call this a "soft-link" because of the substantial problems in consistency and convergence of iterative solution algorithms.

We still stand in need of a clear argument for how rationality leads to the anomalism principle; there are the substantial problems surrounding the status of the causal closure of the physical and its bearing on monism; and the cause-law principle's strictness requirement is still in need of a compelling rationale.

Combined bottom-up and top-down approaches can be categorized following Böhringer and Rutherford [32]: Coupling existing large-scale bottom-up and top-down models [46]; Böhringer and Rutherford call this a "soft-link" because of the substantial problems in consistency and convergence of iterative solution algorithms.

It didn't solve the substantial problems of poverty in America; of our stinginess when it comes to food support.

Unfortunately, the vast majority of studies conducted in support of split-foveal processing fail to adhere to either of these requirements (for a description of the substantial problems that exist in previous research in this area, see [4], [5]).

We acknowledge that there are additional issues that arise when conducting individual patient data reviews (Stewart and Clarke, 1995), especially cost and time, but these have to be weighed against the substantial problems we encountered.