Sentence examples for the substantial difficulty from inspiring English sources

We use some approaches to prove the global existence-boundedness of classical solutions and overcome the substantial difficulty of the existence of a nonlinear prey-taxis term.

These results show the substantial difficulty associated with the aim of searching for all published cases.

A major drawback has been the substantial difficulty in designing HIF-specific inhibitors owing to the intracellular nature of the protein complex and the lack of active sites to which small molecular inhibitors are usually designed (Scheuermann et al., 2013).

Much of the problem arises from the substantial difficulties that media faces in China.

The Dutch transport industry, like others in cities across the world, underestimated the substantial difficulties that they would face in forcing passengers to adopt a new payment system.

16 Classical approaches require twin and family samples, the availability of which is limited by the substantial difficulties and high costs inherent in their recruitment.

Adding accurate laboratory testing data to ILI addresses the otherwise substantial difficulty in estimating ILI consultations due to influenza, and results in estimates that are less sensitive to parameter misspecification.

But, he said, 10percentt of the patients had substantial difficulty acknowledging the nature and severity of their disease, a problem that could call their decision-making capacity into question.

All (four) patients in the 2100-mg cohadt had substantial difficulty with the capsule load (seven capsules of 300 mg BID).

In the present case a substantial difficulty arises from the fact that, beside imposing the volume constraint ({mathcal H}^n(Q(Gamma ))=omega _n) and that the barycenter of (Gamma ) is at the origin, we have also to fix some second order quantities.

Imagine giving players on the ATP Tour only one serve, which would automatically drop serve speeds, and you would start to see the men having substantial difficulty holding serve as well.